Product ID:08453 ZOSYN
MSDS Date:11/02/1993
FSC:6505
NIIN:00F043803
MSDS Number: CDFWD

WYETH-AYERST (DIVISION OF AMERICAN HOME PRODUCTS)

150 A1 RADNOR CHESTER RD
SAINT DAVIDS, PA 19087-5000
US

Emergency Phone: 610-902-5171/800-666-7248

Info Phone: 610-902-5171/800-666-7248

Cage: GO449

WYETH-AYERST (DIVISION OF AMERICAN HOME PRODUCTS)

SAINT DAVIDS, PA 19087-5000 US

Telephone: 610-902-5171/800-666-7248

Cage: GO449

TAZOBACTAM, SODIUM SALT *96-4*

CAS: 89785-84-2

RTECS: XI0191500

SODIUM BICARBONATE

CAS: 144-55-8

RTECS: VZ0950000

Fraction By Weight: 2.5-5%

PIPERACILLIN, T 1220

CAS: 61477-96-1

RTECS: XH8952200

PIPERACILLIN SODIUM, PENTCILLIN *96-4*

CAS: 59703-84-3

RTECS: XI0180000

TAZOBACTAM

CAS: 89786-04-9

LD50 LC50 Mixture:ORAL LD50(RATS): 4220 MG/KG (SEE SUPP)
Routes of Entry: Inhalation:YES Skin:NO Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:EYES: MAY CAUSE IRRITATION.
INHALATION: IRRITATION OF THE RESPIRATORY TRACT. INGESTION:
GASTROINTESTINAL SYMPTOMS MAY OCCUR. ALSO SKIN REACTIONS, SYSTEMIC
ALLERGIC REACTIONS; LIVER FUNCTION ABNORMALIT IES.
Explanation of Carcinogenicity:NONE
Effects of Overexposure:IRRITATION, DIARRHEA, NAUSEA, VOMITING, RASH,
PRURITUS, SEVERE ITCHING, ERYTHEMA (REDNESS)
Medical Cond Aggravated by Exposure:PERSONS ALLERGIC TO
PENICILLIN/CEPHALOSPORIN-TYPE ANTIBIOTICS/OTHER B-LACTAMASE
INHIBITORS.

First Aid:EYES: IMMEDIATELY FLUSH W/PLENTY OF COOL, LOW-PRESSURE WATER
FOR 20 MINS. SKIN: PROMPTLY WASH W/SOAP & COOL RUNNING WATER.
INHALATION: REMOVE TO FRESH AIR. GIVE CPR/OXGYEN IF NECESSARY.
INGESTION: DON 'T INDUCE VOMITING EXCEPT AS DIRECTED BY MEDICAL
PERSONNEL. NEVER GIVE ANYTHING BY MOUTH IF UNCONSCIOUS. NEVER
INDUCE VOMITING IF UNCONSCIOUS. OBTAIN MEDICAL ATTENTION IN ALL
CASES.

Unusual Fire/Explosion Hazard:WHEN HEATED TO DECOMPOSITION, POSSIBLY
EMITS VERY TOXIC FUMES OF SULFUR CONTAINING COMPOUNDS.

Spill Release Procedures:WEAR DISPOSABLE COVERALLS, RUBBER GLOVES & AN
APPROVED FULL-FACE, AIR PURIFYING RESPIRATOR W/HIGH-EFFICIENCY
CARTRIDGES/A SELF CONTAINED /SUPPLIED-AIR RESPIRATOR, CONTAIN &
COLLECT MATERIALS.

Handling and Storage Precautions:VIALS CONTAINING LYOPHILIZED
PIPERACILLIN/TAZOBACTAM SHOULD BE STORED AT CONTROLLED ROOM TEMP
59-86F & USED W/IN 24 HR AFTER STORAGE AT ROOM TEMP.
Other Precautions:FOR LONGER TERM STORAGE, RECONSTITUTED VIALS SHOULD
BE STORED UNDER REFRIGERATION 36-46F & IF NOT USED, DISCARDED AFTER
7 DAYS. MINIMIZE EXCESS HANDLING. KEEP CONTAINER CLOSED WHEN NOT IN
USE.

Respiratory Protection:WHEN ENGINEERING CONTROLS AREN'T ADEQUATE TO
CONTAIN DUST/MIST, WEAR AN APPROVED AIR-PURIFYING RESPIRATOR
W/HIGH-EFFICIENCY CARTRIDGES/A SUPPLIED-AIR RESPIRATOR.
Ventilation:USE CLOSED-SYSTEM HANDLING, LABORATORY BENCH HOOD/LOCAL
EXHAUST VENTILATION TO CONTROL DUST/MIST.
Protective Gloves:RUBBER
Eye Protection:REQUIRED
Work Hygienic Practices:REMOVE/LAUNDER CONTAMINATED CLOTHING BEFORE
REUSE. DESTROY CONTAMINATED LEATHER ITEMS.
Supplemental Safety and Health
INFORMATION FOR ORAL LD50 IS FOR SODIUM BICARBONATE.

Melt/Freeze Pt:M.P/F.P Text:311F
Spec Gravity:1.0512
pH:6.8
Solubility in Water:MODERATE
Appearance and Odor:WHITE TO OFF-WHITE SUSPENSION
Percent Volatiles by Volume:80

Stability Indicator/Materials to Avoid:YES
STRONG OXIDIZERS & STRONG BASES
Hazardous Decomposition Products:HYDROGEN SULFIDE, SULFUR DIOXIDE/OTHER
SULFUR CONTAINING COMPOUNDS

Waste Disposal Methods:DISPOSE OF IN ACCORDANCE W/LOCAL, STATE &
FEDERAL REGULATIONS. INCINERATION IS RECOMMENDED.

Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.